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doi: 10.1016/j.ceca.2021.102514 6 FunaroAHorensteinALCalossoLMorraMTaroccoRPFrancoLet al

Daratumumab has direct and indirect anti-cancer activity by binding to CD38, inducing direct apoptosis of tumor cells and triggering complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) [64]