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12 Although EMT endows CTCs with partial resistance to anoikis, the overexpression of TrkB, a neurotrophic tyrosine kinase receptor, also contributes to protection from apoptosis by activating the phosphatidylinositol 3-kinase (PI3K)AKT survival pathway

In the MPP + -induced PD cell model (SH-SY5Y), SIRT1 expression was similarly upregulated (Fig

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While there is no evidence of common structural or functional brain alterations in PAIS, probably due to its heterogeneous origin and lack of conceptualization, ME/CFS has been extensively studied with MRI (magnetic resonance imaging), as recently reviewed by Nelson et al

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