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The reason is that you'd be hitting the mitochondria from several directions at once, i.e

Resolution of liver enlargement following cessation of treatment is influenced largely by the rate of elimination of the xenobiotic or its metabolite from the body

During the review process, we found that the circulatory, nervous, endocrine, and immune systems play critical roles in mediating interorgan interactions and regulating communication and functional coordination between organs

Further longitudinal and experimental studies are warranted to validate these findings and assess their clinical implications

Although some nanomedicines have shown potential mitochondrial targeting, nanomedicines still face several challenges from experimental to clinical practice