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Description

A meta-analysis revealed that, compared with the GLP-1R agonists, placebo, and insulin, tirzepatide significantly reduced body mass index, waist circumference, and body weight [75]

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The hippocampus serves as a critical region of interest in this study for two key reasons: once the aforementioned ghrelin-mediated influence on hippocampal neurogenesis and synaptic plasticity, and the established role of the hippocampus in the pathophysiology of major depression 40 , highlighting its relevance to obesity-depression comorbidity