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Drug approval (NDA/BLA) requires demonstration of both safety AND efficacy for a specific disease indication through controlled clinical trials

HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K/Akt, MAPK and STAT3, in CT26 murine cells

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Here are some additional strategies to manage dyskinesias: It is important to note that mild dyskinesia may not be bothersome, and the mobility afforded by taking levodopa may be preferable to the immobility associated with not taking levodopa