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Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface

the starting DNA segments are reassembled (&/or subjected to one or more directed evolution methods described herein) to generate a library of recombinant DNA segments varying in size which will include full length coding sequences and any essential regulatory the starting DNA segments are reassembled (&/or subjected to one or more directed evolution methods described herein) by any of the sequence reassembly (&/or one or more additional directed evolution methods described herein) formats provided herein to generate a diverse library of recombinant DNA segments

This is the basis for oral and capsule research formats, especially in gut-focused models

Maximal effects typically occur at four to six weeks, with full tissue remodeling continuing over three to six months

Aug 2016;30(4):733-56