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This causes continuous stimulation, preventing normal neuromuscular transmission as long as the drug remains bound (Figure 2)

The raw movies were motion-corrected and fractionated to 0.98, 1.03, 0.972 and 0.98 e per 2 per frame, respectively, and dose-weighted using RELIONs implementation of MotionCor2

AGOmiRNA complexes were prepared largely as described 51,71

However, with our busy lifestyles, its easy to neglect this

In addition, the reduction of non-native disulphide bonds would lead to an increase in the level of GSSG, particularly if the resulting cysteine residues remain reduced or reform native disulphide bonds through an Ero1-catalysed oxidative pathway