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What You Should Know NAD+ functions as a coenzyme for energy metabolism and activates repair proteins called sirtuins Glutathione neutralizes free radicals and supports detoxification as your primary antioxidant defense From ages 20 to 60, NAD+ drops by 50%, while glutathione synthesis decreases by 45% The molecules support one another through NADPH production pathways that regenerate active glutathione

doi: 10.1007/S00216-024-05364-Z 8

Phase I detoxification uses cytochrome P450 enzymes to break down toxins, but this process often creates highly reactive, intermediate metabolites that are actually more toxic than the original substance

failure of this regulation allows excessive IL-1 and IL-18 production, amplifying systemic inflammation, which is particularly relevant in SLE and RA