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Metabolomic and lipidomic profiling of matched primary and mCRC specimens has revealed site-specific lipid signaturesincluding elevated lysophosphatidylcholines in liver metastases and increased sphingolipid species in peritoneal depositsthat may serve as biomarkers of metastatic niche adaptation [12]

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In addition, statins seems to contribute to slow down the progression of fibrosis and reduce the incidence of hepatocellular carcinoma in cirrhotic patients ( On the other hand, some patients present class and dose-dependent adverse effects in muscle, liver and other tissues (Medina-Caliz et al., 2016