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No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern

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This dual mechanism provides more potent appetite suppression and metabolic improvement than GLP-1 agonists alone

The main therapeutic goals often include: Enhancing lipolysis , or the breakdown of stored fat