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Geffner, D

Over the past decade, immunotherapy has reshaped the treatment landscape for several malignancies, offering durable responses and long-term survival where chemotherapy historically provided only temporary control

Future research should focus on elucidating the precise molecular pathways involved in oxidative stress and exploring novel antioxidant therapies that could restore balance to the redox environment within the testes, ultimately enhancing fertility outcomes in affected individuals ( 2.3 Destruction of the blood-testis barrier and induction of autoimmune responses The blood-testis barrier (BTB) serves as a critical protective structure that maintains the immunological privilege of the testicular environment, allowing for the development of germ cells without interference from the immune system ( Moreover, the breakdown of the BTB is not merely a localized phenomenon