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Analysis of oxidative stress-induced cellular senescence Cell senescence assay was conducted with Senescence -Galactosidase Staining Kit (Cell Signaling Technology) according to the manufacturers instruction

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Proline and its metabolites regulate gene expression, mTOR pathway (van Meijl et al., 2010), protein synthesis, cell survival, and scavenge free radicals (Kaul et al., 2008)

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