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Description

Upregulation of the activity of Nrf2 and, subsequently, the antioxidant enzymes, could prevent the onset of DR complications in diabetic patients

hence, interest in their pharmacological inhibition has increased

In studies combining NNMTi with other weightloss drugs, coadministration with GLP1 receptor agonists significantly enhances weightloss efficacy while reducing side effects such as nausea and vomiting commonly associated with GLP1 agonists