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Large-scale, randomized controlled trials are necessary to determine whether coenzyme Q 10 , in conjunction with vitamin E, has therapeutic benefit in FRDA

For example, reduced levels of Lactobacillus species were observed in mouse models of cancer cachexia, and Lactobacillus supplementation attenuated muscle wasting in these models, suggesting that Lactobacillus supplementation may serve as a potential therapeutic avenue for cachexia-related muscle atrophy

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In Group I, liver sections exhibited a faint positive cytoplasmic immunoreaction for all markers, indicating low basal expression levels (Fig