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Avoid standard oral B12 supplements under 1000 micrograms they fail to correct deficiency in most cases

It works through a different mechanism than GHK-Cu: PDRN activates the A2A adenosine receptor, which triggers tissue regeneration, dampens inflammation, and supports the cellular metabolism of dermal cells

Submission to the Medicines Classification Committee

Therapeutic Goods Administration

As stated in the CY 2025 PFS proposed rule (89 FR 61969), we do not intend to conduct separate outlier analysis of PDE for the purposes of the Medicare Part D Drug Inflation Rebate Program, but we did consider several adjustments to reduce the effect of outliers not resolved through the Part D payment reconciliation process, including ( removal of PDE records that were identified by CMS as having potential outlier quantity dispensed fields but were neither corrected nor verified by Part D plan sponsors, removal of the quantity dispensed field for certain records at or above a certain statistically derived threshold, and imputing quantity dispensed values for such records