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Collectively, the current ligand fishing studies have identified a group of GST binding partners not previously identified in experiments conducted in recombinant bacteria

10,11,12,13,14,15,16,17 The clinical findings observed in this small group of patients served as a basis for establishing diagnostic criteria, with severe skin fragility, sagging, and redundant skin as major clinical criteria, and a soft, doughy skin texture, easy bruising, premature rupture of fetal membranes, and large hernias (umbilical, inguinal) as minor criteria