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Jun-Ichi T, Hajime N, Katsuaki T, Masahiko I, Atsushi N, Norio U et al

Nrf2 inhibits LXR-dependent hepatic lipogenesis by competing with FXR for acetylase binding

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Specifically, chronic inflammation and oxidative stress damage the vasa nervorum the microscopic capillary networks that supply oxygen and nutrients to the peripheral nerves

Additionally, inhaled delivery avoids first pass metabolism, provides direct treatment, and potentially limits systemic off-target effects making it ideal for pulmonary protection [97]