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Once the rash appears, the bullseye rash in particular is a telltale sign of Lyme disease, even though some patients never get one

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References Frost C, Nepal S, Wang J, et al

centrally, a harmful inability to drain venous blood adequately for a given cerebral blood inflow without raising venous pressures was resolved, evidencing rapid counteraction of such venous and intracranial hypertension [20,58,59,60,61,62]