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Concomitant administration of topiramate with valproic acid has also been associated with hypothermia in patients who have tolerated either drug alone

This early finding suggests that it is eliminated from the body fairly rapidly, and probably does not pose too much of a risk of building up to dangerous levels if taken for extended periods nonetheless, more studies in human users will be needed to know for sure, so this should not be considered a definitive finding until more research is done

This cyclical relationship explains why the l arginine vs citrulline question often leads formulators toward combination approaches rather than single-ingredient strategies

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