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[14] Chelation therapy itself began during World War II when chemists at the University of Oxford searched for an antidote for lewisite, an arsenic-based chemical weapon

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Ergothioneine is taken up by endothelial cells via SLC22A4 (Reference Li, Yang and Sit88) , where it has been demonstrated to limit reactive oxygen species production and damage from a variety of insults, including hyperglycaemia, through multiple mechanisms (Reference Li, Yang and Sit88,Reference DOnofrio, Servillo and Giovane89)

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In contrast, the use of PET imaging in a human study revealed that individuals carrying the ApoE4 gene variant show significantly higher levels of tau deposition, even when there are no A plaques present