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1022,1023 Newer inhibitors such as TVB-316 and TVB-2640 have shown reduced toxicity and are currently in trials for non-small cell lung cancer, prostate cancer, and HER2-positive metastatic breast cancer (NCT 03808558, NCT 03179904, and NCT 05743621)

"Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase." Journal of Medicinal Chemistry

Yet another compound, Honokiol (HKL), has been shown to protect against doxorubicin-induced cardiotoxicity by activating SIRT3, which helps reduce ROS production, prevent mitochondrial fragmentation, and promote mitochondrial fusion 187

However, these panels require validation in diverse populations before clinical implementation (Nisenblat et al., 2016)

Refrain from taking antihistamines 24 hours before the procedure