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Additionally, extracellular matrix (ECM) proteins secreted by adipocytes not only determine the architecture of the adipose tissue but also have the capacity to promote inflammation and regulate systemic metabolism

It also modulates neurotransmitters 8 like dopamine and GABA

10.1038/nprot.2013.099 4 BelogurovG

385 Mitochondrial respiratory dysfunction, resulting in ATP reduction and energy metabolism disorders, will further affect normal cell functions, leading to organ dysfunction