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Notably, targeted inhibition of NRF2 with Brusatol counteracts this effect, effectively suppressing NRF2 activity and inducing apoptosis in breast cancer cells both in vitro and in vivo [170]

In silico prediction and structure-based multitargeted molecular docking analysis of selected bioactive compounds against mucormycosis

The absence of pronounced negative sign( 2 ) spikes further confirms the lack of significant hydrogen bonding or electrostatic attraction, while the positive sign( 2 ) regions are largely associated with steric repulsion within the fullerene framework itself rather than destabilizing hostguest interactions