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Individuals 65 years and older with comorbidities, are more susceptible to become infected with SARS-CoV-2 and become critically ill and are more prone to develop ARDS and require mechanical ventilation, having a high 28-day mortality rate (Yang X

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Therefore, the discussion of PDK-driven immune modulation in this review is necessarily concise and highlights an important area requiring further investigation, particularly in the current era of immunotherapy