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Avoid ice directly on skin, as this can cause additional tissue damage

It interacts with nitric oxide pathways and various growth factors to promote healing

But if people ask me, Would you take it? I would say no, citing worries about the long-term effects on things like tumor growth and whether it can enhance already proven levers like good nutrition, sleep, and rehab

Comparative analysis of the expression of c-Fos and interleukin-2 proteins in hypothalamus cells during various treatments

That mechanism is why clinicians reach for it first for age-related GH decline: energy, sleep quality, recovery, and body composition are the common goals