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GSH-triggered prodrugs Because intracellular GSH levels are typically elevated in tumor cells relative to normal tissues, this redox imbalance has been exploited as a tumor-associated trigger for prodrug activation and selective cytotoxicity 214

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Adding CJC/Ipa brings injection-site reactions and mild water retention

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In silico studies show that curcumin, when combined with chemotherapy drugs, exhibit strong interactions with target proteins, with curcumin achieving the highest interaction scores with marker proteins, and curcumin derivatives fitting well in the active site of target proteins, suggesting their potential as effective anticancer agents for breast cancer [267, 268]