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HTC-based conversion of BRD4 ligands into degraders To evaluate the extensibility of this approach, we sought to convert JQ1, a potent and selective BET (BRD2, BRD3 and BRD4) bromodomain ligand 59 , into molecular glue degraders, several of which have been reported recently 23,24,25,34,60,61

NPI-001 has the potential to treat a broad set of diseases and conditions associated with oxidative stress and reduced glutathione levels such as slowing or stopping disease progression in retinitis pigmentosa patients with functional cones, regardless of their disease-causing genetic mutation

Due to variations between the in vivo and in vitro environments, this signal-to-concentration conversion may induce some error in the actual value of the HO concentration detected in vivo

59 mtDNA-encoded proteins are mainly involved in the respiratory chain and are therefore key components of cellular energy production