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When NNMT becomes overactive, particularly in adipose tissue, it depletes cellular NAD+ reserves while promoting fat storage and metabolic inefficiency

In addition to epilepsy, generalized developmental delay, coma, tachycardia, generalized hypotonia, profound hypotonia, microcephaly, active tendon reflexes, and loss of tendon reflexes may be present

Individuals with active cancer or a history of malignancy should avoid the peptide unless under medical supervision, as effects on tumor growth have not been adequately studied