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2 Essential functions of oligodendrocytes and myelination 2.1 The basic functions of oligodendrocytes 2.1.1 Oligodendrocytes form myelin sheath Oligodendrocytes are glial cells in the CNS, a class of multifunctional neuroglia primarily located in the white matter of the CNS ( 2.1.2 Oligodendrocytes provide metabolic support Oligodendrocytes also deliver metabolic support to axons ( 2.1.3 Oligodendrocytes regulate neural plasticity Oligodendrocytes play a crucial role in modulating neural plasticity through dynamic signaling interactions, thereby preserving the functional integrity of brain networks and supporting neurodevelopment and cerebral homeostasis ( Oligodendrocytes play a pivotal role in enhancing synaptic plasticity through the secretion of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), and metabolic substrates like lactate, thereby directly influencing neuronal survival and functional activity ( 2.2 Basic functions of myelin sheath The myelin sheath is rich in lipids (70%) and proteins (30%), including myelin basic protein (MBP) and proteolipid protein (PLP)

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This versatile platform has been applied in cancer therapy and arthritis models, though endogenous biotin in vivo may interfere, and the SA protein itself can trigger immune responses with repeated administration [141]

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