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(2) obtain baseline data (symptom scores, basic labs, possibly zonulin or lactulose/mannitol testing where appropriate and available)

Tuna is one of the most widely consumed seafoods globally and represents an accessible, affordable B12 source for many people

Observational studies A large number of cross-sectional and prospective cohort studies have associated elevated blood homocysteine concentrations with measures of poor cognitive scores and increased risk of dementia, including Alzheimer's disease (reviewed in 67, 69)