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As expected, BM ADO concentrations showed substantial inter-patient variability, consistent with previous reports describing wide fluctuations among MM patients ( Table 2 Individual patient values for ADO and INO concentrations in bone marrow and peripheral blood at baseline (pre-start) and at DARA treatment failure

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Vascular ingrowth at the injury site is another documented effect, with new capillary networks supplying oxygen and nutrients necessary for sustained regenerative activity