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However, Cas9-induced double-stranded DNA breaks can cause cytotoxicity, influencing proliferation and differentiation decisions 33,34 , whereas acquired genetic and epigenetic variation in source iPS cells 35,36 , and patterning biases 37 and cell stress 38 during differentiation, can influence cell-type fidelity and fate specification in organoid models

These results provide additional support for the ability of NINJ1 to regulate ferroptosis by class I FIN but not other classes of FINs

Cell 143 , 813825 (2010)

synthesized evidence showing that dietary interventions significantly modulate inflammatory and oxidative pathways in chronic autoimmune arthritis, underscoring the transdiagnostic relevance of dietinflammation mechanisms and supporting the plausibility of similar effects in BD [29]

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