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Finally, the pleiotropy-original sin hypothesis postulates that cell death is an immanent and inevitable process associated with the formation of metabolic by-products in cells like reactive oxygen species (ROS) and cell death machinery components-encoding genes were not initially related to cell death processes and performed pro-survival functions

That means: Hypokalemia can develop or worsen which can lead to: Cardiac arrhythmias Muscle weakness QT prolongation In severe cases, sudden cardiovascular instability This is a classic board-style pearl that many clinicians forget because B12 feels benign. But in profoundly deficient patientsespecially those with severe megaloblastic anemiarepletion is metabolically active treatment

The clinical potential of articular cartilage-derived progenitor cells: a systematic review

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