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The intricate biology of GBM reflects the complex interplay of signaling pathways such as PI3K/Akt/mTOR, MAPK, and NF-B, which drive tumor proliferation, metabolic reprogramming, immune evasion, and angiogenesis

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Similar content being viewed by others Main Aging of the immune system has dramatic consequences on host physiology, reducing tissue regeneration and turnover 1 , lowering the establishment and maintenance of lasting immune memory 2 , and increasing the risk for chronic infections 3 and autoimmune diseases 4

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