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Description

This signaling cascade induces the expression of IL-6 that function as an autocrine factor which induces the EMT program (Fig

In the BRAF mutant cell lines M229P and M238P, we observed that cell lines begin with different initial differentiation stages as defined by their subtype signatures, but shift notably towards the undifferentiated signature upon acquired resistance to vemurafenib (M229R, M238R) (Figure 2A)