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5-Amino-1MQ blocks NNMT, which in preclinical models frees up more of that precursor and lifts NAD+ inside fat tissue

The safety profile of 5-Amino-1MQ rests largely on preclinical rodent models, in which the compound was well tolerated and did not produce obvious organ toxicity

Likewise, the treatment of SEV group cultures with B12 brought the mRNA levels of most of the evaluated biomarkers closer to those of untreated CTRL ( Figures 3A, B, D )

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The intensity of the pink color correlates with B12 concentration