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Nevertheless, these studies mainly used disulfide-thiol exchange to deplete GSH for GPX4 inactivation, which is difficult to inactivate GPX4 completely because of the compensatory effect of the continuous synthesis of GSH

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Internal radiation therapy includes brachytherapy, where a source of radiation is implanted [4], intraoperative radiotherapy, or radionuclide therapy, where therapeutic radionuclides are administered parenterally [5]