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Acute lethal effects of neonicotinoids have already been described in mammals in case of severe overdoses, although its mechanism of action is highly selective for insects, acting on the nicotinic acetylcholine receptors in their central nervous systems 9

Conclusions: These findings suggest a new link between low peripheral serotonin, L-carnitine, and fatigue

Even when homocysteine levels are normal, risks may arise from impaired methylation, folate bioavailability, and environmental exposures

Since this SSE is associated with a loss of sensitivity and accuracy, the above-mentioned sample preparation methods describe compromises between the minimization of these matrix effects by removing matrix components during sample clean-up, and the ability to detect a broad spectrum of analytes with reasonable sample preparation efforts and adequate sensitivity