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Therefore, most cancer cells rely on nutrient transporters that can import extracellular cystine (the oxidized dimer form of cysteine) (, which is a sodium-independent, chloride-dependent, anionic L-cystine/L-glutamate antiporter on the cell surface ( SLC7A11 gene in humans is located on chromosome 4 and the SLC7A11 protein has orthologs in all vertebrates ( and, therefore, serves as the primary transporter for cystine and glutamate ( Extracellular cystine is imported into the cell through SLC7A11 and is converted to cysteine through a NADPH-consuming reduction reaction in the highly reducing atmosphere of the cytosol

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Moreover, EGR1 was found to boost the enzymatic function of PFKB3, leading to the secretion of inflammatory factors like ICAM-1, TNF-, IL-6, and MCP-1 from endothelial cells through enhanced glycolysis, ultimately causing inflammatory damage [6]

Based on the analyses summarized above, we present a schematic diagram to explain the mechanisms of the effects of Al on NO 3 - uptake ( Figure 2 )