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The gut flora interact with toll-like receptors (TLRs) that are the gatekeepers in helping distinguish which antigens are helpful or harmful[93], and composition of the gut flora directly influences intestinal permeability.[94] There is growing data showing a potential therapeutic benefit of probiotics in the treatment of IBS.[95][96][97][98][99] The most positive single-species studies for IBS have shown the specific strain Bifidobacterium infantis ( B

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Interventions that limit myeloid cell activation in the TME or immune cell trafficking to the tumor tissue may limit immunotherapy when not given concomitantly with drivers of appropriate inflammation such as ICB or PRR agonists