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AXL participates in the appearance of CD11 c high spinal dorsal horn microglia to induce the expression of IGF-1, promoting the relief of PNI induced neuropathic pain[35]

10.1007/s000180050041 24 DavletovaS.RizhskyL.LiangH.ShengqiangZ.OliverD

Therefore, this review aims to summarize the regulation of metabolism on inflammatory response and oxidative stress in the pathogenesis of ARDS, explain the regulatory effects of various metabolites and the mechanisms involved, and finally introduce the current potential therapeutic drugs for metabolic regulation in ARDS

Proline is exceptional in that it has an R group that folds back and covalently bonds to the backbone of the amino acid, creating a more rigid element in a protein chain that reduces free movement of the polypeptide chain