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In pregnant and breastfeeding women, vitamin B12 deficiency might cause neural tube defects, developmental delays, failure to thrive, and anemia in offspring

J Inherit Metab Dis 28:818, PMID: 15702408 Pastore A, Petrillo S, Tozzi G, Carrozzo R, Martinelli D, Dionisi-Vici C, Di Giovamberardino G, Ceravolo F, Klein MB, Miller G, Enns GM, Bertini E, Piemonte F (2013) Glutathione: a redox signature in monitoring EPI-743 therapy in children with mitochondrial encephalomyopathies

Its debatable if that even penetrates the skin

seven subjects were on antidiabetic medications, and six subjects were on statins

Individual response varies considerably, with some noticing effects earlier than others