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An altered respiratory microbiome in COPD patients (e.g., decreased Firmicutes and Bifidobacterium abundances) is also associated with increased risk of PD [5, 7, 62, 63]

Redox regulation of oxygen-sensitive transcription factors The major determinant of the redox status in mammalian cells is glutathione (L--glutamyl-L-cysteinyl-glycine), a tripeptide thiol [14, 18, 4750, 107]

Alterations in iron availability not only impact mucosal immunity but may also drive oxidative stress and lipid peroxidation, thereby facilitating malignant transformation

Possible involvement of eicosanoids in the pharmacological action of bromelain

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