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These include- Aged over 75 Decreased stomach acid Frequent use of antacids Autoimmune conditions affecting the stomach High doses of folic acid Stomach surgery Prolonged use of metformin Adoption of a vegan or vegetarian diet Excessive alcohol consumption How Does Vitamin B12 Benefit Your Body

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Using the same experimental methodology, additional NAPRT inhibitors were annotated, including pyrazinoic acid (with an apparent Ki of 75 m), 2-fluoronicotinic acid (apparent Ki = 280 m), and several non-steroidal anti-inflammatory drugs (NSAIDs) such as flufenamic acid (Ki = 46 M), mefenamic acid (Ki = 76 M), and salicylic acid and phenylbutazone (both had an apparent Ki = 160 M) [84,85]