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Growth hormone receptor antagonist treatment reduces exercise performance in young males

Holford, J., et al

In this regard, it is interesting that NLRP3-independent inflammasome stimuli, such as the AIM2 ligand poly(dA:dT) and the NLRC4 activator flagellin, have also been reported to increase levels of ubiquitylated IL-1 49

These findings position oxioptosis as a redox-sensitive death switch with dual therapeutic implicationsleveraging its cytotoxicity against resistant malignancies while mitigating oxidative tissue damage (Xuan et al., 2022) (Figure 11)

In this context, Ca 2+ becomes not only a symptom-associated factor but also a unifying mechanistic link in disease progression and a potential target for symptom relief and disease control