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It is appreciated that, despite its intrinsic process-related limitations (in the types of favored &/or allowed mutagenesis processes) and in its speed, natural evolution has had the advantage of having been in process for millions of years & and throughout a wide diversity of environments

Elevated homocysteine suggests insufficiency of B12, folate, or B6 affecting cellular methylation pathways critical for metabolism, detoxification, and DNA synthesis

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a Hazard ratios are not adjusted for multiplicity or for stratification variables