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A potential role for a secretory granule-associated ARF6 protein

diabetes obesity, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis (NASH), a cardiovascular disease or any other disease/disorder involving GLP-1 (including any disease/disorder involving, or mediated by, a deficiency of GLP-1 or deficient GLP-1 signalling), using the solid oral pharmaceutical composition provided herein

The difference between benefit and harm is clinical rigour

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This could be explained either by the simulated anthropogenic variability being too low, as suggested by Casado et al