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Integrating lifestyle-based interventions with mechanistically informed molecular research may ultimately provide a rational strategy to address the multifactorial pathogenesis of diabetic retinopathy

Their secretion of matrix metalloproteinases (MMPs), serine proteases, and cathepsins disrupts the endothelial basement membranes, degrades extracellular matrix components, including collagen, and facilitates the migration of tumor and stromal cells, ultimately promoting tumor angiogenesis and metastasis ( Dixon defined ferroptosis as a unique type of controlled cell death in 2012, based on its iron-dependent mechanism and fundamental deviations from apoptotic pathways ( Figure 3 )

Collagen Production Upregulates synthesis of types I, III, and IV collagen the scaffolding of youthful skin