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In vivo, SLU-PP-332 increases oxidative fiber markers (for example, type IIa), cytochrome-c content, mitochondrial DNA abundance, and expression of OXPHOS genes

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The most modulated genes found through the network approach were SIRT3, FOXO1, and PPARGC1A, these proteins were also found to have the highest docking results, several studies have reported the role of these proteins in the modulation of ROS and oxidative stress via mitochondria, as ROS and oxidative stress have been reported to alter various cellular signaling pathways and cause neuronal death