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[4] It can be caused by nutrient deficiencies and impaired ADME, which can both result in low selenium levels and higher thyroid antibody levels

Accuracy statistics for LVO detection were: specificity 86% (95%CI 82%-90%), sensitivity 51% (95%CI 37%-65%), NPV 90% (95%CI 86%-93%), PPV 42% (95%CI 30%-55%)

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The response of GH secretion to exogenous ghrelin is significantly blunted in obese patients and this response is restored early on after Roux-en-Y gastric bypass (prior to any major weight loss), suggesting that there is an intrinsic resistance to ghrelin in obesity which is reversed with gastric bypass, and which is not linked to weight loss (525)

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